Hormonal links in Lipoedema
Lipoedema is a loose connective tissue disease characterized by the disproportionate accumulation of fibrotic subcutaneous adipose tissue and extracellular fluid in the limbs of women due to microvascular inflammation.
There are gaps in knowledge regarding lipoedema development but what is known that hormonal imbalances, in particular oestrogen and oestrogen receptors are the contributing factors to this condition.
Oestrogen controls the distribution of body fat and food intake, regulates leptin expression, increases insulin sensitivity, and reduces inflammation through signaling pathways mediated by its receptors, estrogen receptor alpha (ERα) and ERβ. The decrease of ERα and increased ERβ concentration results in excess fat commonly stored in the gluteal-femoral region. Fluctuation of hormones in puberty and perimenopause, the drop of oestrogen in menopause may contribute to lipoedema development and it’s progression
Manual lymph drainage (MLD), compression garments, and physical exercise can improve lipoedema symptoms such as pain, sensitivity to pressure, tendency to swellings especially at the early stage of this condition.
Balancing the hormones and reducing inflammation could be an answer to stop lipoedema progression.
Lipoedema is a loose connective tissue disease characterized by the disproportionate accumulation of fibrotic subcutaneous adipose tissue and extracellular fluid in the limbs of women due to microvascular inflammation.
There are gaps in knowledge regarding lipoedema development but what is known that hormonal imbalances, in particular oestrogen and oestrogen receptors are the contributing factors to this condition.
Oestrogen controls the distribution of body fat and food intake, regulates leptin expression, increases insulin sensitivity, and reduces inflammation through signaling pathways mediated by its receptors, estrogen receptor alpha (ERα) and ERβ. The decrease of ERα and increased ERβ concentration results in excess fat commonly stored in the gluteal-femoral region. Fluctuation of hormones in puberty and perimenopause, the drop of oestrogen in menopause may contribute to lipoedema development and it’s progression
Manual lymph drainage (MLD), compression garments, and physical exercise can improve lipoedema symptoms such as pain, sensitivity to pressure, tendency to swellings especially at the early stage of this condition.
Balancing the hormones and reducing inflammation could be an answer to stop lipoedema progression.
